WebJul 1, 2008 · The identification of additional cis-elements in gcg promoter that mediate the stimulatory effect of cAMP partially explained why deleting or mutating the CRE motif in the gcg promoter only partially attenuated the effect of cAMP elevation (Furstenau et al. 1999, Gevrey et al. 2004). However, it cannot explain moderate but significant ... WebFeb 14, 2013 · The stimulation of gcg transcription in endocrine L cells by lithium or cAMP is at least partially mediated by increasing the binding of β-cat/TCF7L2 to the G2 enhancer element of gcg promoter (27–29). The role of Wnt signaling in brain GLP-1 expression and metabolic homeostasis is unknown.
Context-dependency of synthetic minimal promoters in driving …
WebJul 25, 2024 · We have designed a double-stranded adeno-associated virus containing a rat proglucagon promoter (700 bp) driving enhanced green … WebMar 9, 2024 · In the AAV-GCG promoter-driven Cre virus used to infuse into the pancreas of ROSA26 tomato reporter mice, we observed 85%–90% Cre cleaved red fluorescence … is hope credit the same as hope scholarship
Pdx1 and MafA Producing Cells by Short Glucagon Promoter ... - Resear…
WebOct 26, 2024 · MST1R (RON) is a receptor of the MET tyrosine kinase receptor family involved in several cancers such as pancreas, breast, ovary, colon, and stomach. Some studies have shown that overexpression of MST1R increases the migratory and invasive properties of cancer cells. The promoter region of the oncogene MST1R is enriched in … WebSep 7, 2024 · Previously, we have also generated Gcg-Cre transgenic mice using an 8 kb mouse Gcg promoter and codon-optimised Cre (improved Cre; iCre) , and other groups have developed Gcg-Cre mice using a … WebDec 1, 2024 · A transgenic Gcg-Cre rat model expresses iCre under control of the Gcg promoter.. iCre is expressed by GLP1-positive cells in the hindbrain, pancreas, and intestine.. Additional brain regions display transient and/or very low levels of Gcg expression. +/+ Gcg-Cre rats display a marked knockdown of Gcg mRNA and GLP1 … is hope floats on disney plus