Tīmeklis2013. gada 22. aug. · CGs are a specialized form of secretory lysosomes and contain granzymes, perforin, granulysin, cathepsins, and the lysosome-associated membrane proteins CD107a/LAMP-1, CD107b/LAMP-2, and CD63/LAMP-3. 4-9 Perforin can bind to the target cell’s membrane and mediates the delivery of granzymes into the … Tīmeklis2024. gada 5. maijs · Interestingly, the expression of LAMP1 on astrocytes correlated with the expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a ligand causing apoptosis upon binding respective death receptors. This increased TRAIL expression might influence T cell apoptosis and thus regulate EAE outcome.

Surface CD107a/LAMP-1 protects natural killer cells from degranulation ...

Tīmeklis2016. gada 16. maijs · LAMP1 was directly regulated by tumor-suppressive miR-320a and contributed to cancer cell aggressiveness. The identification of novel … TīmeklisLAMP1, as a marker of the lysosome has been used to assess the number of lysosomes. Downregulation of LAMP1 inhibited PCa cell proliferation, invasion, and … eyedeals eyewear

Expression of the lysosomal-associated membrane protein-1

Tīmekliswe demonstrate that LAMP1 is a direct target in UBL4A-induced tumor suppression and inhibition of autophagy. HPbetaCD and HPgammaCD facilitate cholesterol … Tīmeklis2024. gada 1. aug. · LAMP proteins are involved in many different aspects of cell biology and can influence cellular processes such as phagocytosis, autophagy, lipid transport, and aging. Interestingly, for all the five members identified so far (LAMP1, LAMP2, LAMP3, CD68/Macrosialin/LAMP4, and BAD-LAMP/LAMP5), a role in cancer has … TīmeklisLAMP1 is the major carrier of poly-N-acetyllactosamine (polyLacNAc) on B16F10 cells. However, significantly higher expression of mutLAMP1 had no effect on … eyedeals eyecare minneapolis